This page is a web portal to datasets that we have generated from single cells (Drop-seq) or single nuclei (DroNc-seq).
Please visit the follow link to view single cell RNAseq data obtained from 9-month-old APP/PS1 mice and wild-type littermate controls. This "Borchelt" mouse model overexpresses the APP and PS1 transgenes with familial mutations associated with Alzheimer's disease. At this cell number and sequencing depth, we have identified 2 clear populations of activated astrocytes and microglia.